An antigenic determinant (epitope) unique to a single clone of cells and located in the variable region of the immunoglobulin product of that clone or to the T-cell receptor. The idiotope forms part of the antigen-binding site. Any single immunoglobulin may have more than one idiotope. Idiotopes are also associated with the antigen-binding sites of T-cell receptors and are the epitopes to which an anti-idiotype antibody or T-cell binds.

Dictionary of molecular biology. 2004.

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  • idiotope — Single antigenic determinant of an idiotype. SEE ALSO: idiotypic antigenic determinant. SYN: idiotypic antigenic determinant. [idio + tope] set of idiotopes (antigenic determinants) of either the immunoglobulin or T cell receptor v …   Medical dictionary

  • idiotope — …   Useful english dictionary

  • Idiotopes — An idiotope is the unique set of antigenic determinants of the variable portion of an antibody.cite web |url= hl dorlands.jspzQzpgzEzzSzppdocszSzuszSzcommonzSzdorlandszSzdorlandzSzdmd i 01zPzhtm… …   Wikipedia

  • Idiotype — In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules based upon the antigen binding specificity and therefore structure of their variable region. The variable region of antigen …   Wikipedia

  • antibody — An immunoglobulin molecule produced by B lymphoid cells with a specific amino acid sequence evoked in humans or other animals by an antigen (immunogen). These molecules are characterized by reacting specifically with the antigen in some… …   Medical dictionary

  • Anti-idiotypic — vaccines comprise antibodies that have three dimensional immunogenic regions, designated idiotopes, that consist of protein sequences that bind to cell receptors. Idiotopes are aggregated into idiotypes specific of their target antigen.… …   Wikipedia

  • paratope — In immune network theory, an idiotope; an antigenic site of an antibody that is responsible for that antibody binding to an antigenic determinant (epitope). Also used of the site on a ligand molecule to which a cell surface receptor binds …   Dictionary of molecular biology

  • allotope — The antigenic determinant on the constant or nonvariable region of an allotype. [allo + tope] * * * al·lo·tope (alґo tōp) a site on the constant or nonvarying portion of an antibody molecule that can be recognized by a combining site of… …   Medical dictionary

  • determinant — The factor that contributes to the generation of a trait. [L. determans, determining, limiting] allotypic determinants antigenic determinants of allotypes. antigenic d. the particular chemical group of a molecule that determines immunological… …   Medical dictionary

  • idiotype — Collection of idiotopes within the variable region that confers on an immunoglobulin molecule an antigenic “individuality” and is frequently a unique attribute of a given antibody in a given animal. It is the product of a limited number of B… …   Medical dictionary

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